Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection (2024)

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Sayed Haidar Abbas Raza

Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University

,

Guangzhou 510642

,

China

Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University

,

Shaoguan 512005

,

China

College of Animal Science and Technology, Northwest A&F University

,

Yangling, Shaanxi 712100

,

P.R. China

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,

Ruimin Zhong

Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University

,

Shaoguan 512005

,

China

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,

Xiangmei Li

Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University

,

Guangzhou 510642

,

China

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,

Sameer D Pant

Gulbali Institute, Charles Sturt University

,

Wagga Wagga, NSW 2678

,

Australia

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,

Xing Shen

Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University

,

Guangzhou 510642

,

China

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Mona N BinMowyna

College of Education, Shaqra University

,

Shaqra 11911

,

Saudi Arabia

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Lin Luo

Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University

,

Guangzhou 510642

,

China

Corresponding author. Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. E-mail: lin.luo@scau.edu.cn

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Hongtao Lei

Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University

,

Guangzhou 510642

,

China

Guangdong Laboratory for Lingnan Modern Agriculture

,

Guangzhou 510642

,

China

Corresponding author. Guangdong Provincial Key Laboratory of Food Quality and Safety, South China Agricultural University, Guangzhou 510642, China. E-mail: hongtao@scau.edu.cn

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Journal of Pharmacy and Pharmacology, rgae133, https://doi.org/10.1093/jpp/rgae133

Published:

25 October 2024

Article history

Received:

18 June 2024

Accepted:

04 October 2024

Published:

25 October 2024

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    Sayed Haidar Abbas Raza, Ruimin Zhong, Xiangmei Li, Sameer D Pant, Xing Shen, Mona N BinMowyna, Lin Luo, Hongtao Lei, Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection, Journal of Pharmacy and Pharmacology, 2024;, rgae133, https://doi.org/10.1093/jpp/rgae133

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Abstract

Objectives

Ganoderma lucidum (GL) is a white rot fungus widely used for its pharmacological properties and health benefits. GL consists of several biological components, including polysaccharides, sterols, and triterpenoids. Triterpenoids are often found in GL in the form of lanostane-type triterpenoids with quadrilateral carbon structures.

Key findings

The study revealed that triterpenoids have diverse biological properties and can be categorized based on their functional groups. Triterpenoids derived from GL have shown potential medicinal applications. They can disrupt the cell cycle by inhibiting β-catenin or protein kinase C activity, leading to anti-cancer, anti-inflammatory, and anti-diabetic effects. They can also reduce the production of inflammatory cytokines, thus mitigating inflammation. Additionally, triterpenoids have been found to enhance the immune system’s defenses against various health conditions. They possess antioxidant, antiparasitic, anti-hyperlipidemic, and antimicrobial activities, making them suitable for pharmaceutical applications. Furthermore, triterpenoids are believed to afford radioprotection to DNA, protecting it from radiation damage.

Summary

This review focuses on the types of triterpenoids isolated from GL, their synthesis pathways, and their chemical structures. Additionally, it highlights the pharmacological characteristics of triterpenoids derived from GL, emphasizing their significant role in various therapeutic applications and health benefits for both humans and animals.

Ganoderma lucidum triterpenoids investigating their role in medicinal applications and genomic protection (4)

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Ganoderma lucidum, triterpenoids, therapeutic applications, genomic guardian

© The Author(s) 2024. Published by Oxford University Press on behalf of the Royal Pharmaceutical Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site—for further information please contact journals.permissions@oup.com.

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